Heart Disease
America's number 1 killer
Treating cardiovascular disease
Cardiologywith a difference
Over 25% of Americans die from heart attack
Coronary artery disease is the clogging or blockage of the coronary arteries caused by atherosclerosis.
High cholesterol diets, lack of exercise or your genetics can cause cholesterol to build up in the arteries.
655,000 Americans die each year from heart disease.
What if we could simply melt the plaque away?
Breakthrough Discovery !
German scientists discover treatment to remove plaque
In 2016 a team of scientists from Germany's Bonn University discovered
a new compound that reduced plaque in mice by over 40% in as little as 4 weeks.
The new cyclodextrin compound (CAVADEX®) was also tested on human plaque and they discovered it affected the plaque in a similar way.
Atherosclerotic plaque in mice significantly reduced after 4 weeks treatment
Angiogram: First patient has plaque reduction in just 4 weeks
CHOLREM Pty Ltd LEADS THE WORLD IN RESEARCH
CAVADEX® was administered to our first patient in our Melbourne clinic in April 2019 and within 4 weeks the plaque was reduced.
CAVADEX® circulates around the cardiovascular system removing
built up cholesterol and plaque resulting in significant plaque reduction.
CAVADEX® is absorbed via intravenous application or as an enema only. If taken orally it is destroyed in the gut and has no effect.
Regular low doses of CAVADEX® can have a significant effect on plaque build up over time.
CAVADEX® developed by Cholrem Pty Ltd
CAVADEX® entraps and removes harmful cholesterol from plaque
The CAVADEX® molecule
CAVADEX® is a form of Hydroxypropyl beta cyclodextrin (HPßCD) that is comprised of seven sugar molecules bound together in a ring (cyclic oligosaccharide).
The ring-shaped, three-dimensional structure has a hydrophobic cavity in its center, which is capable of trapping cholesterol and lipids. It has been used extensively as an excipient in the food, deodorant, and drug industry for the past century, and it is generally recognized as safe (GRAS).
As an active ingredient, CAVADEX® entraps and removes intracellular cholesterol and lipids that can cause injury to the kidneys and other organs, including the brain and liver.
Source: Lopez CA, de Vries AH, Marrink SJ (2011) Molecular Mechanism of Cyclodextrin Mediated Cholesterol Extraction. PLoS Comput Biol 7(3): e1002020. doi:10.1371/journal.pcbi.1002020.
Cholrem® is not orally bioavailable due to its high molecular weight and resistance to digestive enzymes, and therefore must be administered intravenously or as an enema.
CAVADEXReduces cholesterol
from arteries
products containing CAVADEX®
remchol for home
RemChol delivers CAVADEX® via an enema, up to 1 gram of CAVADEX® is absorbed into the blood stream and can be applied as often as once a day.
Available now
Related Media Articles
"Soaked up cholesterol and removed it..."
sciencedaily.com : New hope for treating atheriosclerosis
Scientific Papers
Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming
2-Hydroxypropyl-b-cyclodextrin (HP-b-CD): A toxicology review
"Back to the Future: A New Look at Hydroxypropyl-Beta-Cyclodextrins
Systemic administration of 2-hydroxypropyl-b-cyclodextrin.....
Hydroxypropyl-Beta-Cyclodextrin Reduces Inflammatory Signaling from Monocytes:.....